Description

HGH Fragment 176-191

Description

The HGH Fragment is a modified form of amino acids 176-191 of the human Growth

Hormone (GH) polypeptide. This peptide, as the name implies, is a piece of the 191

amino chain that makes up growth hormone, from positions 176 through 191 to be

exact. This fragment has been shown to induce lipolysis, or fat breakdown, and

even inhibits lipogenesis, which is the transformation of food materials into fat

stored in the body. Research studies have shown that these happens both to

humans and to animals. This short amino-acid chain that make up Fragment 176 is

only about 10% of the length of the entire strand of growth hormone and seems to

have no other typical positive or negative effects that growth hormone does such as

actual growth of tissues or insulin resistance.

HGH Fragment (176-191) is a sterile, non-pyrogenic, white lyophilized powder

intended for subcutaneous or intramuscular injection, after reconstitution with

sterile Water for Injection.

Mechanism of Action

Investigators and scientists at several studies and researches discovered that the

fat-reducing effects of GH appear to be controlled by a small region near one end of

the GH molecule. This region consists of amino acids 176-191, and is less than 10%

of the total size of the GH molecule and appears to have no effect on growth or

insulin resistance. It works by mimicking the way natural GH regulates fat

metabolism but without the adverse effects on blood sugar or growth that is seen

with unmodified GH.

More specifically, GH cannot be used as an anti-obesity treatment due to adverse

effects:

• Fluid retention
• Diabetogenic (in high doses)

On the contrary, HGH fragment can produce ac inhibition of LPL activity in adipose

tissue and stimulate lipolysis in adipocytes. At the same time, HGH fragment

appears to have no effect on growth or insulin resistance. In that way treatment with

HGH fragment can not cause diabetogenic problems or influence the insulin

metabolism. Also HGH fragment can not cause fluid retention.

These segments of the synthetic peptides HGH Fragment (176-191) have been

investigated for their in vivo effects in laboratory mice musculus. Research results

have shown that HGH Fragment (176-191) have resulted to a short-period increase in

blood glucose and a more sustained increase in plasma insulin, together with other

fragments such as 172-191, 177-191 and 178-191. In addition, the researchers

have suggested that functionality of the peptide depends not only in the

informational sequence but should also have the correct physical configuration.

Also, this fragment, being a region of high accessibility to proteases and also rich in

praline, have been demonstrated to affect the conformational change in the

cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as

the hinge for the pivoting of the two subdomains. This then suggest that such

residue is significant in conformational changes be serving as sites for peripheral

protein binding in some body cells.

In another study on animal subjects, they found out that a 500mcg dosage of the

said hormone increased the lipolytic activity in adipose tissues without having negative

influence in the blood glucose level. Futhermore, though it behaves like a

human growth hormone (HGH), it does not causes hyperglycemia because it does

not compete with HGH receptors.

Because of such effects, researchers have suggested that it might be used for the

elimination of excess abdominal fat which is < significant aspect of HIV-associated

lipodystrophy.

Other studies claimed that protein peptide HGH fragment (176-191) actually acts on the

reduction of excessive adipose tissues (body fat) such as those in the abdominal area

and increases muscle mass while enhancing the lipid content of the body. In laboratory

tests on fat cells from humans, HGH fragment released fat specifically from obese fat

cells but not from lean ones, reduced new fat accumulation in all fat cells and

enchanced the burning of fat. HGH fragment reduces body fat in obese subjects and

enhanced fat burning without changing food consumption or inducing growth (as it dies

not increase IGF levels) or any other unwanted GH effect.

So as a conclusion, HGH fragment:

• Reduces the most stubborn abdominal fat.
• Does not negatively impact blood glucose levels.
• Increases energy expenditure.
• Cell proliferation doesn’t occur.
• Improves lipid profiles and lipolytic activity.
• Is an extremely potent and effective fat burner.

Adverse reactions

Since only the active fragment of HGH is used, there haven’t been observed any of the

adverse reactions connected with that hormone

Instructions for reconstitution

Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the

rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the

rubber stopper so it goes through the rubber and into the vial. Now, while angling the

needle so that the water for injection goes down the side of the glass, rather than

directly into the powder, inject the water for injection into the vial. Repeat this step until

you have the correct amount of water in the vial. The powder will dissolve quickly,

however it can help to gently roll the vial in between your fingers (do not shake the vial

vigorously). Remove the syringe and dispose of it. You should never re-use a syringe.

Dosage

Recommended dosage of HGH Fragment (176-191):

•  500mcg (0.5 mg) once per day

Storage

• After reconstitution, may be stored for a maximum of 14 days in a refrigirator at 2°C — 8°C.
• Store vials in an upright position.
• Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
• For one month can be stored at room temperature.