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ACVR2B (ACE-031) (10 MG X 10 VIALS)

260.00

SKU: BP-P11 Category:

Description

ACVR2B (ACE-031)

 

Activin Receptor Type II B

 

Description

Ace-031, also known as ACVR2B, is a soluble form of activin type IIB receptor,

which is an inhibitor of myostatin and other naturally occurring proteins that limit

muscle growth. This compound was genetically developed to bind to myostatin

before it can attach to its receptor and halt muscle growth. The two Biopharma

companies that worked on this compound are Acceleron and Shire.

 

Ace-031 is a sterile, non-pyrogenic, white lyophilized powder intended for

subcutaneous or intramuscular injection, after reconstitution with sterile Water for

Injection.

 

Mechanism of Action

ACE-031 is a protein that’s being investigated to determine if it can be used for

therapeutic purpose for building muscle and enhancing the strength of test

subjects. It does this by allowing molecules to bind to cell surface receptors — this is

also where it signals through. These cell surface receptors are known as Activin

Receptor Type II B. ACE-031 is recombinant fusion protein that is produced when a

portion of the ACVR2B receptor and a part of the standard antibody are joined

together. This then creates a decoy version of ACVR2B that circulates and

eliminates proteins like GDF-8 (also known as myostatin) and other molecules

that limits the muscle’s strength of growth.

 

The proteins in the TGF-8 superfamily are used to regulate muscle growth. These

act as the on and off switch for the production of muscles. In order to stop muscle

growth , several molecules, such as GDF-8, intermingle with the ACVR2B receptor,

which stops the production of muscle. When these off switches aren’t present, the

muscle increases in mass radically.

 

Adverse reactions

ACE-031 could have the following side effects:

 

  • Water Retention
  • Bleeding from the nose
  • Increased Hunger
  • Headache
  • Reactions at injection site

 

Instructions for reconstitution

Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the

rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the

rubber stopper so it goes through the rubber and into the vial. Now, while angling the

needle so that the water for injection goes down the side of the glass, rather than

directly into the powder, inject the water for injection into the vial. Repeat this step until

you have the correct amount of water in the vial. The powder will dissolve quickly,

however it can help to gently roll the vial in between your fingers (do not shake the vial

vigorously). Remove the syringe and dispose of it. You should never reuse a syringe.

 

Dosage

Recommended dosage of ACE-031:

  • 500 — 1.000 mcg twice a week

 

Storage

  • After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C — 8°C.
  • Store vials in an upright position.
  • Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
  • For one month can be stored at room temperature.

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