Insulin-Like Growth Factor-1, Long R3
Long[R3] insulin-like growth factor-l (IGF-1 Long[R3]) is a Human Recombinant,
single, non-glycosylated, polypeptide chain containing 83 amino acids. It is a
analog of human IGF-1 comprising the complete human IGF-1 sequence with the
substitution of an Arginine (Arg or R) for the Glutamic Acid (Glu or E) at position 3
(hence R3), and a 13 amino acid extension peptide at the N-terminus. Molecular
Weight: 9111.6 daltons — confirmed by Mass Spectrometry. It is produced in E. coll
using a patented expression system the IGF-I Long[R3] is correctly folded and
purified by several chromatography steps to yield Receptor Grade IGF-I Long[R3].
IGF-1 L[R3] is a sterile, non-pyrogenic, white lyophilized powder intended for
subcutaneous or intramuscular injection, after reconstitution with sterile Water for
Mechanism of Action
This analog has been engineered with the express purpose of increasing biological
activity. IGF-1 Long[R3] is significantly more potent than IGF-1 in vitro and in vivo.
The enhanced potency is due to the markedly decreased binding of IGF-1 Long[R3]
to all IGF binding proteins. These binding proteins normally inhibit the biological
actions of IGFs.
IGF-1 stands for insulin-like growth factor. It is a natural substance that is produced
in the human body and is at its highest natural levels during puberty. During puberty
IGF-1 is the most responsible for the natural muscle growth that occurs during these
few years. There are many different things that IGF-1 does in the human body.
Among the effects the most positive are:
- Increased amino acid transport to cells
- Increased glucose transport
- Increased protein synthesis
- Decreased protein degradation
- Increased RNA synthesis.
When IGF-1 is active it behaves differently in different types of tissues. In muscle
cells proteins and associated cell components are stimulated. Protein synthesis is
increased along with amino acid absorption. As a source of energy, IGF-1 mobilizes
fat for use as energy in adipose tissue. In lean tissue, IGF-1 prevents insulin from
transporting glucose across cell membranes. As a result the colls have to switch to
burning off fat as a source of energy.
IGF-1 also mimic’s insulin in the human body. It makes muscles more sensitive to
insulin’s effects, so if you are a person that currently uses insulin you can lower your
dosage by a decent margin to achieve the same effect, and as mentioned IGF-1 will
keep the insulin from making you fat.
Perhaps the most interesting and potent effect IGF-1 has on the human body is its
ability to cause hyperplasia, which is an actual splitting of cells. Hyperplasia is
significantly different from Hypertrophy. Hypertrophy is simply an increase in the
size of musice cells. After puberty the human body has a set number of muscle cells,
and Hypertrophy is to increase the size of these muscle cells.
But IGF-1 is able to cause hyperplasia which actually increases the number of
muscle cells present irf the tissue. So in a way IGF-1 can actually change your
genetic capabilities in terms of muscle tissue and cell count. IGF-1 proliferates and
differentiates the number of types of cells present. At a genetic level it has the
potential to alter an individuals capacity to build superior muscle density and size.
Regular IGF-1 only has a half-life of about 10-20 minutes if the human body and is
quickly destroyed. The most effective igf analog form of all is IGF-1 L[R3]. Because
of its chemical alteration and the amino acid changes, IGF-1 L[R3] can avoid
binding to proteins in the human body and so to have a much longer half life, around
This list presents the most serious and/or most frequently observed adverse
reactions using IGF-1 or its analogs:
- Users can feel drained and tired all day.
- IGF-1 may cause your hands, fingers and knuckles to ache.
- IGF-1 L[R3] used in larget quantity around the 100mcg+ range may cause headaches,
occasional nausea and can contribute to low blood sugar or hypoglycaemia.
Instructions for reconstitution
Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the
rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the
rubber stopper so it goes through the rubber and into the vial. Now, while angling the
needle so that the water for injection goes down the side of the glass, rather than
directly into the powder, inject the water for injection into the vial. Repeat this step until
you have the correct amount of water in the vial. The powder will dissolve quickly,
however it can help to gently roll the vial in between your fingers (do not shake the vial
vigorously). Remove the syringe and dispose of it. You should never re-use a syringe.
Recommended dosage of IGF-1 L[R3]:
- 50-80 mcg per day.
- After reconstitution, may be stored for a maximum of 14 days in a refrigirator at 2°C — 8°C.
- Store vials in an upright position.
- Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
- For one month can be stored at room temperature.