MT-2 (or Melanotan II) is another synthetic peptide of hormones nature and
lactam cyclic analog of melanocortin protein hormone alpha-melanocyte
stimulating hormone; its molecular weight/mass is 1024.2 with molecular
formula is C50H69N15O9. This analog has typical features of proteins.
MT-2 is a sterile, non-pyrogenic, white lyophilized powder intended for
subcutaneous or intramuscular injection, after reconstitution with sterile
Water for Injection.
Mechanism of Action
MT-II contributes to satiety via a hypothalamic signal. MT-II also affects
skin pigmentation as it is a melanocyte-stimulating hormone (MSH). MT-II
binds to melanocortin receptors and affects the MC4R activity
demonstrating an effect on meal size and choice but not meal frequency.
In a pilot study using human subjects, a significant change in skin
pigmentation (darkening) occurred after just 5 injections of MT-II used
every other day. This same study also noted that males that used MT-II
experienced penile erections concomitantly with “stretching and yawning.”
Between one and five hours after injection of MT-II. Another study found 8
of 10 men increase erectile rigidity to 38 minutes verses 3 minutes with
placebo. The only noted side effects were mild nausea, decreased appetite,
and “stretching and yawning.”.
Another potential benefit of MT-II is its affects on food choice, intake, and
nutrient partitioning. Banno’s study surmised that food intake and body
weight were decreased by chronic administration of MT-II. Insulin
sensitivity as well as glucose tolerance was improved by MT-II. Serum
triglyceride levels were also decreased by MT-II, and the affects persisted
for at least 25 days. Thus one can conclude MT-II could be used to treat
obesity, metabolic syndrome, and any co morbid disorders.
- Facial Flushing
- Injection site reactions
- Zero incidence of erections
- No change in vital signs or haematological parameters, blood biochemistry
(liver and renal function)
Instructions for reconstitution
Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the
rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the
rubber stopper so it goes through the rubber and into the vial. Now, while angling the
needle so that the water for injection goes down the side of the glass, rather than
directly into the powder, inject the water for injection into the vial. Repeat this step until
you have the correct amount of water in the vial. The powder will dissolve quickly,
however it can help to gently roll the vial in between your fingers (do not shake the vial
vigorously). Remove the syringe and dispose of it. You should never re-use a syringe.
Recommended dosage of MT-2:
- 0.25 – 1.5 mg once per day.
- After reconstitution, may be stored for a maximum of 14 days in a refrigirator at 2°C — 8°C.
- Store vials in an upright position.
- Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
- For one month can be stored at room temperature.
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