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DROSTE-MED E (250 MG/ML)

DROSTE-MED E (250 MG/ML)

45.00 

Drostanolone Enanthate, originally introduced by Syntex in the 1970s under the name Masteron and now known as Masteron Enanthate, is a synthetic anabolic steroid in the Dihydrotestosterone (DHT) family. This steroid is particularly valued by athletes for its anti-aromatase properties, preventing the conversion of testosterone into estrogen. With androgenic effects five times stronger than testosterone, Drostanolone Enanthate helps bodybuilders and athletes achieve a more defined and lean physique while promoting rapid fat loss.

Description

DESCRIPTION

Drostanolone Enanthate, originally introduced by Syntex in the 1970s under the name Masteron and now known as Masteron Enanthate, is a synthetic anabolic steroid in the Dihydrotestosterone (DHT) family. This steroid is particularly valued by athletes for its anti-aromatase properties, preventing the conversion of testosterone into estrogen. With androgenic effects five times stronger than testosterone, Drostanolone Enanthate helps bodybuilders and athletes achieve a more defined and lean physique while promoting rapid fat loss.

CLINICAL PHARMACOLOGY

Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and
adverse reactions demonstrate the androgenic properties of these drugs. Complete
dissociation of anabolic and androgenic effects has not been achieved. The actions of
anabolic steroids are thus similar to those of male sex hormones. Anabolic steroids suppress
the gonadotropic functions of the pituitary and may exert a direct effect upon the testes.
During exogenous administration of anabolic androgens, endogenous testosterone release
is inhibited through inhibition of pituitary luteinizing hormone (LH). At large doses,
spermatogenesis may be suppressed through feedback inhibition of pituitary
follicle-stimulating hormone (FSH). Drostanolone attaches to androgen receptors; increasing
nitrogen retention and protein synthesis. Drostanolone acts on DHT modulated pathways as
well, Drostanolone is a potent estrogen antagonist and does not aromatize to estrogen,
limiting expression of side effects often linked to estrogen such as water retention,
gynecomastia, and some types of high blood pressure. Drostanolone undergoes hepatic
metabolism with a half- life of 2-3 days after separation of the ester.

INDICATIONS

To rapidly restore muscle tissue atrophied during recovery from a traumatic injury. To offset
muscle catabolism in patients with a wasting syndrome.DA To treat certain types of anemia
which are non-responsive to first line agents. Oestrogen antagonist in treatment of breast
cancer.

CONTRAINDICATIONS

Not indicated for women, children, or the elderly. Women who are pregnant or may become
pregnant because of possible masculinization of the fetus. Patients with nephrosis or the
nephrotic phase of nephritis. Patients with hypercalcemia. Patients suffering from testicular
cancer, prostate cancer, breast cancer, liver damage, kidney damage, stroke, high blood
pressure, heart disease or respiratory problems.

PRECAUTIONS

Elevated liver enzymes and in rare cases hepatic liver dysfunction may occur. Periodic liver
function should be monitored for changes including serum bilirubin, AST, ALT, and AP.
Edema may be increased in patients on concurrent adrenal cortical steroid or ACTH therapy.
Anabolic steroid hormones may increase low-density lipoproteins (LDL) and decrease high
density lipoproteins (HDL).Lipids levels generally return to normal upon discontinuation of
treatment. Anabolic steroids may reduce clotting factors II, V, VII, and X, and may increase
prothrombin time (PT). Patients should be instructed to report any use of warfarin and any
irregular bleeding.

ADVERSE REACTIONS

Male: Gynecomastia, excessive frequency and duration of penile erections, oligospermia.
Skin and Appendages: Hirsutism, male pattern baldness and acne, gynecomastia.
Fluid/electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and
inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests; rarely,
hepatocellular neoplasms, peliosis hepatitis, hepatic adenomas, and cholestatic hepatitis.
Hematologic: Suppression of clotting factors II, V, VII, & X; bleeding in patients on anticoagulant therapy.

Nervous System: Changes in libido, aggression, headache, anxiety, depression, and
generalized paresthesia.

Metabolic: reduced glucose tolerance, increased creatinine clearance, and inhibition of
gonadotropin secretion.

Other: Serum lipid changes, hypercalcaemia, hypertension, oedema, priapism, and
potentiation of sleep apnea. PATIENT MONITORING Serum Cholesterol, HDL, LDL, TG.
Hemoglobin and Hematocrit, Hepatic function tests – AST/ALT Prostatic specific antigen –
PSA, Testosterone: total, free, and bioavailable. Dihydrotestosterone & Estradiol. Male
patients over 40 should undergo a digital rectal luoR examination and evaluate PSA prior to
androgen use. mo Periodic evaluations of the prostate should continue while on androgen
therapy, especially in patients with difficulty in urination or with changes in voiding habits.

PRESENTATION

Drostanolone Enanthate 250 mg/ml, 10 ml.

STORAGE

Store in a cool dry place between 15 -25°C. Protect from light.

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